Novel therapeutic vulnerabilities in prostate cancer

Our group at the Department of Cancer Biology at the Lerner Research Institute of the Cleveland Clinic is seeking a highly motivated and independent post-doctoral fellow to join our studies to overcome treatment resistance in prostate cancer.

Our laboratory focuses on the transcriptional processes and signal transduction cascades that drive lethal prostate cancer progression. Via mechanistic dissection of these pathways and/or complexes, we strive to develop novel therapeutic targets and treatment approaches and to isolate biomarkers of response to these novel treatments. Examples of research interests and recent studies from our DOD- and NCI-funded research programs include: Wei et al. (European Urology, 2017), Liu et  al. (eLife, 2017), Kumari et al. (Endocrine-Related Cancer, 2017), Venkadakrishnan et al. (Oncogene, 2019).

Specific areas of current research interest include:

1)    Isolating and targeting critical molecular interactions in AR transcriptional complexes

2)    Targeting the action of kinases and identifying kinase substrates that can serve as biomarkers of treatment response

3)    Defining the impact of genomic markers on treatment response to personalize the administration of current prostate cancer drugs

All projects involve clinical validation of laboratory findings using archival and fresh patient specimens and animal models of advanced prostate cancer for translational and therapeutic studies. 

The ideal candidate is highly motivated and driven to succeed in a translational science environment. The candidate should have a recent PhD and expertise in cell biology, molecular biology and preclinical animal studies, and is interested in extrapolating in vitro and in vivo findings to patient specimens and data. Outstanding verbal and communication skills are required. The Cleveland Clinic Lerner Research Institute provides an excellent interactive research environment with access to state-of-the-art equipment and facilities.

Interested applicants should submit a CV and contact information for 3 references to Dr. Hannelore Heemers via email: [email protected].

Assistant Professor — Urologic Oncology Research Facility
UC Davis — Sacramento, CA

The Department of Urologic Surgery at the University of California, Davis, School of Medicine, seeks to recruit for a full-time faculty researcher with an interest in urologic oncology at the Assistant Professor rank in a split Regular Series (50%)/In-Residence Series (50%).  

Please click on the link below for more information and to apply for this job. 

https://recruit.ucdavis.edu/JPF03190

Post Doctoral Position in Tumor Metabolism at Baylor College of Medicine

We are looking to recruit a post-doctoral trainee to work on a project whose focus is to determine the interaction between altered tumor metabolism and microenvironment. This is a 5 year NIH-funded project. The potential candidate should have recently completed their PhD with no post-doctoral training experience.  The candidate should have first author paper(s) from the graduate work. The candidate should have outstanding communication and writing skills and should be a good team player. Prior experience in the area of cancer biology is a plus. Candidate should be able to design logical experiments, execute them, analyze the data, interpret the data as well as demonstrate competency in trouble shooting. On the technical side, the candidate should be well versed with in cell culture, organoid cultures, shRNA based knockdowns, phenotypic assessment using functional studies, QPCR, immunoblot etc. Candidate should also have experience with in vivo work including generation of xenograft tumors, survival surgery and in vivo drug administration. Salary per NIH scale. Interested candidates are requested to send their CV, with a brief write up on their research experience and three names of referees to [email protected]. Baylor College of Medicine is an Equal Opportunity/Affirmative Action/Equal Access Employer.

Tenure-Track Assistant Professor: Biology of Genitourinary Cancers
The University of Chicago: Biological Sciences Division: Ben May Department for Cancer Research

Description
The University of Chicago's Ben May Department for Cancer Research in the Biological Sciences Division (BSD) is searching for a tenure-track assistant professor pursuing research on mechanistic aspects of prostate cancer, bladder cancer, kidney cancer, or related areas.

In line with strategic development of cancer research at the University of Chicago, the appointee would carry out research in areas such as cancer stem cells, tumor microenvironment, tumor metabolism, tumor microbiome, tumor cell migration/invasion/metastasis, amongst other areas relevant to cancers of the genitourinary system. We expect the appointee will receive a secondary appointment in the Department of Surgery, Section of Urology, be proposed for an appointment in the NCI-designated University of Chicago Comprehensive Cancer Center (UCCCC) (http://cancer.uchicago.edu), and collaborate in multi-disciplinary research with colleagues across the Biological Sciences and Physical Sciences Divisions, the University of Chicago Medical Center and the Pritzker School of Molecular Engineering. The appointee will have access to state-of-the-art core facilities and outstanding graduate students affiliated with numerous degree-granting programs in the biological and physical sciences. Equally, the appointee will teach at the undergraduate and graduate level.

Applicants must have a doctoral degree. To be considered, those interested must apply online through the University of Chicago’s Academic Recruitment job board, which uses Interfolio to accept applications:  http://apply.interfolio.com/69404 . Applicants must upload a curriculum vitae with bibliography, a short summary of research plans, and contact information for three references whose letters must be received via Interfolio. Review of applications will begin Nov 1, 2019, and continue until the position is filled.

Equal Employment Opportunity Statement
The University of Chicago is an Affirmative Action/Equal Opportunity/Disabled/Veterans Employer and does not discriminate on the basis of race, color, religion, sex, sexual orientation, gender identity, national or ethnic origin, age, status as an individual with a disability, protected veteran status, genetic information, or other protected classes under the law. For additional information please see the University's Notice of Nondiscrimination.

Job seekers in need of a reasonable accommodation to complete the application process should call 773-702-1032 or email [email protected] with their request.

 Postdoctoral Fellowship Position — Stanford University

 A postdoctoral fellowship position is available immediately in the laboratory of James Brooks in the Department of Urology.  The laboratory uses genomic approaches to understand urological malignancies with the goal of developing biomarkers that can be used in clinical management.  The project focuses on understanding alterations in protein glycosylation using genomic approaches with the goal of understanding whether altered glycosylation can modulate immune response to prostate and kidney cancers.  The project is a collaboration between the Brooks laboratory and the laboratories of Sharon Pitteri and Carolyn Bertozzi.  The Pitteri laboratory uses Mass Spectrometry to study proteomic and glycoproteomic changes in cancer, and the Bertozzi laboratory studies immune modulation modulated through Siglec receptors.  The ultimate goal is to test whether Siglec receptors are biologically relevant to prostate and kidney cancer, whether they correlate with clinical outcomes in clinical samples, and whether they could represent potential targets for immune modulatory therapy.

The successful candidate should be highly motivated and hard working, with outstanding past research success and publication history, with an MD, PhD or MD/PhD degrees, and very strong references. Previous experience in cancer research, molecular biology, biochemistry and animal models would be valuable, but is not essential. The position is fully funded through the NIH.  Interested candidates should contact Dr. Brooks at [email protected].

Vice Chair for Research — Ohio State University